Yuh-Man, wadeley(at)med.muni.cz

Neural development and embryonic stem cell-based developmental modelling

Author: Yuh-Man Wadeley

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This educational article titled “Neural development and embryonic stem cell-based developmental modelling“ describes how to investigate the roles of genes in human neural development using stem cell technologies and molecular biology techniques. This educational article is primarily focused on experimental practices. Thus this article is intended for postgraduate students (e.g. Master student, Diploma, and PhD students). However, the article is also suitable for undergraduate students, who are interested in stem cell biology and molecular biology. In the text, students will learn how to perform basic molecular biology techniques (e.g. gene cloning, making fusion protein, PCR and sequencing), and how to grow and to manipulate human embryonic stem cells (hESCs). Moreover, students will learn how to drive hESCs toward to neural fates.

Basic principles and molecular mechanisms regulating early development of mammals - physiology and pathology

Author: Yuh-Man Wadeley

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This educational text titled “Basic principles and molecular mechanisms regulating early development of mammals - ¬physiology and pathology“ describes how embryogenesis proceeds in mammals. In this text, students will learn how the egg is fertilised, how the fertilised egg survives in the mother’s womb (called implatation), how the fertilised egg divides, how the blastocyst develops, how the implanted blastocyst undergos gastrulation or the three germ layers form, and how the brain, heart, muscle, and internal organs develop. Moreover, if the processes go awry, what the baby will be affected. This educational material is recommened to General Medical, Dental Medical students and the students who are taking a developmental biological course.