Department of Pathophysiology, Faculty of Medicine MU, http://www.med.muni.cz/patfyz/patfyzc.html

This teaching material is intended for students of Dentistry registered for the subject Research Activities in Dentistry. The aim of that subject is to improve the students' knowledge of the scientific advancements in dentistry and closely related fields, to motivate students to participate in research activities, to augment their scientific ambitions and, therefore, to lay grounds for their postgraduate studies and scientific career.

This educational material is intended for students of Dentistry who signed for the subject Research Activities in Dentistry. In this lab seminar, students will acquire practical experience with molecular-biological analyses that are routinely used in the field of Dentistry, both for research purposes and for diagnosis of diseases (not only) of the oral cavity. Students will be tasked with the detection of two single nucleotide polymorphisms in the gene for methylenetetrahydrofolate reductase (MTHFR), an enzyme playing an important role in the folic acid metabolism. Within the scope of this seminar, students will also learn to predict the phenotype (i.e., to predict the ability to metabolize the folic acid) based on the analyzed MTHFR haplogenotype.

Tutorial film “Experimentally induced atherosclerosis in laboratory animal - part 1 and 2 “ is intended for students of Pathophysiology in General Medicine (VLA) and Dental Medicine (ZLA) courses. The film systematically shows the procedure to create an experimental model of atherosclerosis in laboratory animal, surgical techniques, tools and equipment as well as subsequent processing of biological material. It aims to serve as an introduction to the student´s practical work itself.

One of the possible approaches to study human diseases and their complexity is to use non-human experimental model organisms.Electronic downloadable textbook “Pathophysiology practicals for General Medicine and Dental Medicine courses“ for students of pathophysiology in General Medicine (VLA) and Dental Medicine (ZLA) courses aims to serve as a practical manual during the practicals and tutorials.